Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and links to their rpeorts go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

Study Counts

Type	Study_count
Total_Studies	1924
interventional	1481
Observational	422
Registry	21

Studies over Time

```

Interventional Trials

Intervention Type

intervention_type	Study_Count
Drug	385
Drug\|placebo	306
Device	200
Other	192
Behavioral	160
Procedure	49
Device\|Other	21
Biological	12
Device\|Drug	12
Dietary Supplement	12
Behavioral\|Other	10
Behavioral\|Device	9
Drug\|Other	9
Device\|placebo	8
Diagnostic Test	8
Dietary Supplement\|placebo	8
Drug\|Procedure	8
Biological\|Other	5
Other\|Procedure	5
Device\|Procedure	4
Genetic	4
Other\|placebo	4
Biological\|placebo	3
Drug\|Other\|placebo	3
Radiation	3
Behavioral\|Drug	2
Behavioral\|Drug\|placebo\|Procedure	2
Behavioral\|Procedure	2
Biological\|Procedure	2
Device\|Diagnostic Test	2
Device\|Drug\|placebo	2
Drug\|Radiation	2
placebo	2
Behavioral\|Biological\|Diagnostic Test\|Other	1
Behavioral\|Device\|Drug	1
Behavioral\|Dietary Supplement\|placebo	1
Behavioral\|Other\|Procedure	1
Behavioral\|Other\|Radiation	1
Behavioral\|placebo	1
Behavioral\|Radiation	1
Biological\|Drug	1
Combination Product	1
Combination Product\|Drug\|placebo	1
Combination Product\|placebo	1
Device\|Diagnostic Test\|Other	1
Device\|Drug\|Other	1
Device\|Drug\|Other\|placebo	1
Device\|Drug\|Other\|Radiation	1
Device\|Genetic	1
Diagnostic Test\|Drug	1
Diagnostic Test\|Other	1
Dietary Supplement\|Drug\|placebo	1
Dietary Supplement\|Other	1
Drug\|Genetic\|Other	1
Drug\|Other\|Radiation	1
Drug\|Procedure\|Radiation	1
Genetic\|Other	1
placebo\|Procedure	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Weekly studies for each intervention

Studies by Country

Country	Study_Count
United States	551
NA	113
France	108
Italy	46
Canada	42
Germany	38
China	36
Brazil	34
United Kingdom	34
Japan	33
Taiwan	26
Spain	25
Korea, Republic of	24
Portugal	18
Sweden	18
Belgium	17
Israel	17
Netherlands	16
Turkey	15
Switzerland	14
United States\|Canada	12
Denmark	10
Austria	8
Australia	5
Finland	5
Norway	5
Finland\|Sweden	4
Austria\|France\|Germany\|Italy\|Spain\|United Kingdom	3
Cuba	3
Egypt	3
France\|United Kingdom	3
Hong Kong	3
Hungary	3
Malaysia	3
Mexico	3
Slovenia	3
Thailand	3
United States\|Puerto Rico	3
Argentina	2
Austria\|Czech Republic\|Hungary\|India\|Italy\|Korea, Republic of\|Philippines\|Poland\|Russian Federation\|Slovakia\|Spain\|Sweden\|Ukraine\|United Kingdom	2
Belgium\|Germany	2
Ireland	2
New Zealand	2
Poland	2
Singapore	2
South Africa	2
United States\|Argentina\|Belgium\|Bulgaria\|Canada\|Chile\|Colombia\|Croatia\|Finland\|India\|Israel\|Mexico\|New Zealand\|Peru\|Romania\|Russian Federation\|Serbia\|Slovakia\|South Africa\|Sweden\|Ukraine	2
United States\|Austria\|France\|Germany\|Spain	2
United States\|Belgium	2
United States\|Canada\|Czechia\|Poland\|Spain	2
United States\|Canada\|Puerto Rico	2
United States\|Germany	2
United States\|Israel	2
United States\|Netherlands	2
Australia\|Austria\|Croatia\|Czech Republic\|Finland\|France\|Germany\|Hungary\|Israel\|Italy\|New Zealand\|Norway\|Poland\|South Africa\|Spain\|Sweden\|United Kingdom	1
Australia\|Canada\|Finland\|France\|Germany\|Italy\|Japan\|Spain	1
Australia\|Germany\|Sweden\|United Kingdom	1
Australia\|Korea, Republic of\|Malaysia\|Singapore\|Taiwan	1
Australia\|New Zealand	1
Australia\|Philippines\|Taiwan\|Thailand	1
Australia\|Spain	1
Austria\|Belgium\|Bulgaria\|Czech Republic\|France\|Germany\|Hungary\|Italy\|Romania\|Slovakia\|Spain\|Switzerland	1
Austria\|Belgium\|Czech Republic\|South Africa\|Estonia\|France\|Germany\|Hungary\|Israel\|Italy\|Lithuania\|Poland\|Portugal\|Serbia\|Spain\|Sweden\|United Kingdom	1
Austria\|Canada\|Denmark\|France\|Germany\|Morocco\|Netherlands\|Portugal\|South Africa\|Spain\|Sweden\|Tunisia\|United Kingdom	1
Austria\|Canada\|France\|Germany\|South Africa	1
Austria\|Czechia\|France\|Germany\|Netherlands\|Portugal\|Spain\|United Kingdom	1
Austria\|Denmark\|France\|Germany\|Netherlands\|Spain\|United Kingdom	1
Austria\|Finland\|France\|Germany\|Italy\|Netherlands\|Norway\|Romania\|Russian Federation\|South Africa\|Spain\|Sweden\|Ukraine	1
Austria\|France\|Germany\|Italy\|Spain	1
Austria\|France\|Germany\|Netherlands\|Spain\|United Kingdom	1
Austria\|Germany\|Italy\|Spain	1
Austria\|Germany\|United Kingdom	1
Belarus	1
Belgium\|Israel	1
Belgium\|Israel\|Italy\|Netherlands\|United Kingdom	1
Belgium\|Netherlands\|United Kingdom	1
Bolivia	1
Brazil\|Canada	1
Bulgaria\|Canada\|Czechia\|France\|Germany\|Hungary\|Italy\|Poland\|Romania\|Russian Federation\|South Africa\|Spain\|Ukraine\|United Kingdom	1
Bulgaria\|Malta\|Serbia	1
Canada\|Finland\|France\|Netherlands\|Spain\|Switzerland\|United Kingdom	1
Canada\|France\|Germany\|United Kingdom	1
Canada\|United States	1
Chile	1
China\|Japan	1
Czech Republic\|France\|Germany\|Italy\|Serbia\|Spain	1
Czech Republic\|Germany\|Hungary\|Poland\|Romania\|Spain\|United Kingdom	1
Czechia	1
Denmark\|Finland\|Germany\|Ireland\|Sweden\|United Kingdom	1
Finland\|Germany\|Hungary\|Latvia	1
France\|Germany	1
France\|Germany\|Netherlands	1
France\|Netherlands	1
France\|Russian Federation	1
France\|United States\|Austria\|Czechia\|Germany\|Israel\|Italy\|Poland\|Spain	1
Germany\|Ireland	1
Germany\|Poland	1
Germany\|South Africa	1
Germany\|Sweden\|United Kingdom	1
Greece	1
Hungary\|United States\|Belgium\|Czech Republic\|France\|Germany\|Italy\|Poland\|Spain	1
Iceland	1
India	1
India\|Israel\|United Kingdom	1
Israel\|Poland\|Serbia	1
Israel\|Serbia\|United Kingdom	1
Italy\|United States\|Canada\|Czechia\|Germany\|Israel\|Poland\|Serbia	1
Japan\|Korea, Republic of\|Taiwan	1
Jordan	1
Norway\|Sweden\|United Kingdom	1
Peru\|United States\|Argentina\|Australia\|Austria\|Belgium\|Colombia\|France\|Germany\|Greece\|Italy\|Mexico\|Puerto Rico\|Spain	1
Poland\|Portugal\|United States\|Australia\|Czech Republic\|Estonia\|France\|Germany\|India\|Italy\|Lithuania\|Malaysia\|Netherlands\|South Africa\|Spain\|Taiwan\|Thailand\|United Kingdom	1
Poland\|Portugal\|United States\|Australia\|Czech Republic\|Estonia\|Germany\|India\|Italy\|Lithuania\|Malaysia\|Netherlands\|South Africa\|Taiwan\|Thailand	1
Portugal\|Romania\|Ukraine	1
Romania\|Ukraine	1
Romania\|United States\|Austria\|Belgium\|Czechia\|France\|Germany\|Hungary\|Israel\|Netherlands\|Poland\|Serbia\|Spain\|United Kingdom	1
Russian Federation	1
Serbia\|United Kingdom	1
Slovakia	1
Slovakia\|Taiwan	1
Spain\|Sweden\|Switzerland\|Australia\|Austria\|Belgium\|Croatia\|Czech Republic\|Finland\|France\|Germany\|Hungary\|Israel\|Italy\|Netherlands\|New Zealand\|Norway\|Poland\|South Africa\|United Kingdom	1
Sweden\|United Kingdom	1
Switzerland\|United States\|Austria\|Canada\|France\|Germany\|Hungary\|Italy\|Slovakia\|Spain	1
United States\|Albania\|Argentina\|Brazil\|Bulgaria\|Canada\|Chile\|Colombia\|Latvia\|Lithuania\|Peru\|Russian Federation\|Ukraine	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Canada\|France\|Germany\|Italy\|Netherlands\|Spain\|Turkey\|United Kingdom	1
United States\|Argentina\|Austria\|Czech Republic\|Finland\|Germany\|Hungary\|India\|Japan\|Malaysia\|Russian Federation\|Slovakia\|Taiwan\|Ukraine	1
United States\|Argentina\|Brazil\|Bulgaria\|Canada\|Chile\|Colombia\|Croatia\|Czech Republic\|Finland\|Germany\|India\|Italy\|Mexico\|Peru\|Poland\|Portugal\|Slovakia\|South Africa\|Spain	1
United States\|Argentina\|Brazil\|Bulgaria\|Canada\|Chile\|Colombia\|Latvia\|Lithuania\|Peru\|Russian Federation\|Ukraine	1
United States\|Argentina\|Canada\|Chile\|Romania\|Ukraine	1
United States\|Argentina\|Chile\|Estonia\|Korea, Republic of\|Russian Federation\|Slovakia	1
United States\|Argentina\|Mexico\|Puerto Rico	1
United States\|Australia	1
United States\|Australia\|Austria\|Belgium\|Canada\|Estonia\|France\|Germany\|Hungary\|India\|Israel\|Korea, Republic of\|Malaysia\|Netherlands\|New Zealand\|Slovakia\|Spain\|Switzerland\|Taiwan\|Thailand\|United Kingdom	1
United States\|Australia\|Austria\|Finland\|Germany\|Hungary\|Italy\|New Zealand\|Poland\|South Africa\|Spain\|United Kingdom	1
United States\|Australia\|Austria\|France\|Germany\|Greece\|Israel\|Italy\|Norway\|Spain\|United Kingdom	1
United States\|Australia\|Belgium\|Canada\|Denmark\|Germany\|Italy\|Japan\|Netherlands\|Russian Federation\|Spain\|Sweden\|United Kingdom	1
United States\|Australia\|Belgium\|Canada\|Denmark\|Italy\|Japan\|Netherlands\|Spain\|United Kingdom	1
United States\|Australia\|Canada\|Czech Republic\|Finland\|Germany\|Israel\|Italy\|Netherlands\|New Zealand\|Poland\|Portugal\|Russian Federation\|Spain\|Thailand\|United Kingdom	1
United States\|Australia\|Canada\|Czechia\|Israel\|New Zealand\|Poland\|Portugal\|Russian Federation\|Thailand\|United Kingdom	1
United States\|Australia\|Canada\|France\|Germany\|Italy	1
United States\|Australia\|Canada\|Germany\|Greece\|Italy\|Korea, Republic of\|Spain\|Sweden	1
United States\|Australia\|France	1
United States\|Austria\|Belgium\|Canada\|Finland\|France\|Germany\|Greece\|Italy\|Spain\|Sweden\|Switzerland\|Turkey\|United Kingdom	1
United States\|Austria\|Belgium\|Canada\|France\|India\|Italy\|Poland\|Portugal\|Russian Federation\|Serbia\|Sweden\|Ukraine\|United Kingdom	1
United States\|Austria\|Belgium\|Italy\|Poland\|Portugal\|Serbia\|Spain\|Sweden	1
United States\|Austria\|Canada\|Czechia\|France\|Germany\|Italy	1
United States\|Austria\|Canada\|France	1
United States\|Austria\|Canada\|France\|Germany\|Greece\|Israel\|Italy\|Japan\|Norway\|Portugal\|Singapore\|Spain\|Sweden\|Taiwan\|United Kingdom	1
United States\|Austria\|Canada\|France\|Germany\|Hungary\|Italy\|Slovakia\|Spain\|Switzerland	1
United States\|Austria\|Canada\|France\|Germany\|Israel\|Italy\|Spain\|United Kingdom	1
United States\|Austria\|Canada\|France\|Germany\|Italy\|Spain\|United Kingdom	1
United States\|Austria\|Czech Republic\|Finland\|France\|Germany\|Hungary\|India\|Japan\|Malaysia\|Netherlands\|Russian Federation\|Slovakia\|Taiwan\|Ukraine	1
United States\|Austria\|Czechia\|Hungary\|Israel\|Poland\|Spain	1
United States\|Austria\|Finland\|France\|Germany\|Italy\|Japan\|Spain\|Sweden\|United Kingdom	1
United States\|Austria\|France\|Germany	1
United States\|Austria\|France\|Germany\|Spain\|United Kingdom	1
United States\|Austria\|Germany\|Israel\|Italy\|South Africa\|Spain\|United Kingdom	1
United States\|Austria\|Hungary\|Poland\|Slovakia\|Slovenia\|Spain	1
United States\|Austria\|Israel\|Italy	1
United States\|Belgium\|Bulgaria\|Canada\|France\|Germany\|Hungary\|Portugal\|Romania\|South Africa\|United Kingdom	1
United States\|Belgium\|Czech Republic\|France\|Hungary\|Italy\|Poland\|Spain\|United Kingdom	1
United States\|Belgium\|France	1
United States\|Belgium\|Germany\|Italy\|Poland\|Spain	1
United States\|Brazil\|Canada\|France\|Germany\|Italy\|Netherlands\|Portugal\|United Kingdom	1
United States\|Bulgaria\|France\|India\|Russian Federation\|Ukraine\|United Kingdom	1
United States\|Canada\|Czech Republic\|France\|Germany\|Hungary\|Poland\|Romania\|Serbia\|United Kingdom	1
United States\|Canada\|Czech Republic\|Germany\|Israel\|Italy\|Poland\|Serbia	1
United States\|Canada\|Czechia\|Israel\|Italy\|Poland\|Portugal\|Turkey	1
United States\|Canada\|Estonia\|Germany\|Latvia\|Lithuania\|Poland\|Romania\|Spain\|Ukraine	1
United States\|Canada\|Estonia\|Latvia\|Lithuania\|Romania\|Ukraine	1
United States\|Canada\|France\|Germany\|Hungary\|Italy\|Spain	1
United States\|Canada\|France\|Germany\|Poland\|Romania\|Spain\|Ukraine	1
United States\|Canada\|Germany\|Spain	1
United States\|Canada\|Israel\|Italy\|Korea, Republic of\|Spain\|Taiwan\|United Kingdom	1
United States\|Canada\|Israel\|Norway\|Spain\|United Kingdom	1
United States\|Chile\|India\|Mexico\|Peru	1
United States\|Czechia\|France\|Germany\|Hungary	1
United States\|Czechia\|France\|Germany\|Italy\|Spain	1
United States\|Czechia\|France\|Germany\|Italy\|Spain\|United Kingdom	1
United States\|Estonia\|Germany\|Hungary\|Poland\|Slovakia	1
United States\|Estonia\|Korea, Republic of\|Russian Federation\|Slovakia	1
United States\|Finland\|Greece\|Hungary\|Italy\|Slovakia\|Spain	1
United States\|France\|Germany\|Italy	1
United States\|Germany\|New Zealand	1
United States\|Germany\|Poland\|Slovakia	1
United States\|Germany\|United Kingdom	1
United States\|Guatemala\|Romania	1
United States\|Hungary\|Poland\|Slovakia\|Spain	1
United States\|India	1
United States\|India\|Italy	1
United States\|Italy	1
United States\|Italy\|Serbia\|United Kingdom	1
United States\|Korea, Republic of\|Malaysia\|Singapore\|Taiwan	1
United States\|New Zealand	1
United States\|Spain	1
United States\|United Kingdom	1

Sites per Study

Site_count	Study_Count
1	1034
2	93
3	36
4	22
5	19
6	13
7	18
8	13
9	7
10	7
11	12
12	11
13	8
14	3
15	10
16	6
17	5
18	9
19	2
20	12
21	7
22	5
23	2
24	7
25	4
26	2
27	2
28	2
29	4
31	4
32	4
33	4
34	3
36	2
38	2
39	3
40	1
41	1
42	5
45	2
46	2
47	3
50	2
51	2
52	2
53	2
54	2
55	3
56	1
57	2
58	1
60	3
61	2
62	1
63	2
65	2
70	2
73	3
74	2
75	4
76	4
77	3
78	2
81	2
83	1
87	3
89	2
95	1
99	1
102	1
105	1
111	1
114	1
118	1
119	1
121	1
125	1
127	1
128	1
130	1
135	2

Phase

Phase	Study_Count
N/A	638
Phase 2	273
Phase 1	189
Phase 3	181
Phase 4	96
Phase 1/Phase 2	56
Phase 2/Phase 3	30
Early Phase 1	18

Number of Arms

Number_of_Arms	Count_of_Studies
1	324
2	714
3	182
4	94
5	27
6	8
7	3
8	5
9	2
11	1
14	2
NA	119

Number of Updates

Count of Versions	Count of Studies
1	179
2	249
3	200
4	173
5	138
6	88
7	73
8	59
9	41
10	34
11	28
12	27
13	20
14	18
15	13
16	13
17	7
18	12
19	11
20	14
21	9
22	8
23	6
24	10
25	3
26	4
27	2
28	3
29	2
30	3
31	2
32	4
33	7
34	2
36	3
37	1
38	1
39	2
50	2
51	2
52	2
60	2
64	1
73	1
86	1
110	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	8405	1302	6.455453
Contacts/Locations	4003	1068	3.748127
Recruitment Status	1817	1057	1.719016
None (earliest Version on record)	1481	1481	1.000000
Study Design	1382	903	1.530454
Outcome Measures	1130	646	1.749226
Eligibility	831	455	1.826374
Interventions	805	526	1.530418
Arms	804	526	1.528517
Study Identification	747	444	1.682432
Sponsor/Collaborators	740	447	1.655481
Study Description	650	419	1.551313
Oversight	562	437	1.286041
More Information	317	118	2.686441
Results	245	245	1.000000
References	239	186	1.284946
Conditions	226	163	1.386503
IPDSharing	152	131	1.160305
Baseline Characteristics	94	76	1.236842
Results Submission Events	81	81	1.000000
Reported Adverse Events	65	55	1.181818
Participant Flow	61	50	1.220000
Documents	50	47	1.063830
2020 Arms	1	1	1.000000
2020Recruitment Status	1	1	1.000000
Quality Control Review has not concludedReturned: June 10	1	1	1.000000
Quality Control Review has not concludedReturned: June 17	1	1	1.000000

Enrollment Metrics by Phase

Measure	Early.Phase.1	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	4.00	2.0000	3.00000	4.00000	2.0000	11.0000	1.0000	5.0000
1st Qu.	16.25	20.0000	16.00000	15.00000	26.5000	36.0000	106.2500	28.0000
Median	20.50	37.0000	25.00000	22.00000	49.0000	70.0000	254.0000	57.5000
Mean	25.50	161.2229	33.42473	38.46429	469.8155	106.5517	284.6839	144.6771
3rd Qu.	30.00	71.0000	45.75000	40.00000	105.5000	149.0000	403.0000	132.0000
Max.	75.00	53480.0000	158.00000	301.00000	100000.0000	420.0000	1174.0000	3500.0000

Trial Group Type

group_type	Group_Count
Experimental	1646
Active Comparator	557
Placebo Comparator	398
Other	171
NA	119
No Intervention	114
Sham Comparator	89

Intervention Model

intervention_model	Study_Count
Parallel Assignment	811
Single Group Assignment	394
Crossover Assignment	206
NA	30
Sequential Assignment	23
Factorial Assignment	17

Primary Purpose

primary_purpose	Study_Count
Treatment	1110
Basic Science	82
Other	74
Diagnostic	67
Supportive Care	63
NA	28
Prevention	22
Health Services Research	17
Screening	9
Device Feasibility	8
Educational/Counseling/Training	1

Observational Studies

Studies by Country

Country	Study_Count
United States	193
NA	41
France	28
China	22
Germany	15
Italy	14
United Kingdom	11
Canada	10
Japan	8
Denmark	7
Turkey	7
Taiwan	6
Netherlands	5
Spain	4
United States\|Canada	4
Finland	3
Switzerland	3
Austria	2
Egypt	2
Israel	2
Korea, Republic of	2
Austria\|Canada\|Croatia\|Czechia\|Greece\|Hungary\|Ireland\|Israel\|Romania\|Spain\|Sweden	1
Austria\|Estonia\|Kazakhstan\|Romania\|Serbia\|Slovakia\|Slovenia	1
Austria\|France\|Germany\|Italy\|Netherlands\|Spain\|Switzerland\|United Kingdom	1
Austria\|Germany	1
Belgium\|France\|Germany\|Italy	1
Belgium\|France\|Italy\|Switzerland\|Turkey	1
Brazil	1
Brazil\|China	1
Croatia\|Czech Republic\|Estonia\|Hungary\|Romania\|Russian Federation\|Serbia\|Slovakia\|Slovenia	1
Croatia\|France\|Germany\|Slovenia	1
Denmark\|Italy\|Czechia\|Germany\|Greece\|Mexico\|Romania\|Slovakia\|Spain\|Switzerland	1
Estonia\|Latvia\|Romania\|Russian Federation\|Serbia\|Slovakia\|Slovenia\|Ukraine	1
France\|Germany	1
France\|Germany\|Italy\|Spain\|United Kingdom	1
France\|Germany\|Turkey	1
France\|Guadeloupe	1
Germany\|Italy\|Spain	1
Germany\|Switzerland	1
Germany\|Thailand	1
Hong Kong	1
Israel\|Italy	1
Malaysia	1
Russian Federation	1
Spain\|United States\|Argentina\|Canada\|France\|Germany\|Hungary\|Israel\|Italy\|Netherlands\|Portugal\|Romania\|United Kingdom	1
Sweden	1
Thailand	1
United States\|Albania\|Belgium\|Brazil\|Germany\|Greece\|Israel\|Italy\|Spain\|Turkey\|United Kingdom	1
United States\|Argentina\|Korea, Republic of\|Spain	1
United States\|Australia\|Belgium\|Hungary\|Israel\|Italy\|Romania\|Slovenia\|Spain\|United Kingdom	1
United States\|Canada\|Israel\|Netherlands	1
United States\|Canada\|Puerto Rico	1
United States\|Germany	1
United States\|Germany\|Italy	1

Sites per Study

Site_count	Study_Count
1	329
2	19
3	11
4	5
5	6
6	4
7	3
8	1
9	1
10	1
12	3
13	2
14	1
15	3
20	1
21	1
24	2
27	2
30	2
32	1
42	1
49	1
52	1
54	2
57	2
58	1
59	1
76	1
98	1
102	1
103	1
118	1
119	1
140	1
211	1
215	1
238	1
273	1
278	1
284	1
311	1
317	1

Number of Updates

Count of Versions	Count of Studies
1	58
2	69
3	59
4	51
5	33
6	30
7	18
8	14
9	15
10	3
11	2
12	5
13	5
14	4
15	4
16	7
17	5
18	4
19	3
20	2
21	1
22	1
23	1
24	2
25	1
26	3
27	2
28	2
32	1
35	1
37	1
38	1
46	1
50	1
64	1
66	1
78	2
93	1
97	1
103	1
110	1
115	1
120	1
123	1
172	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	3310	364	9.093407
Contacts/Locations	988	284	3.478873
Study Description	541	150	3.606667
Study Design	456	255	1.788235
Recruitment Status	452	277	1.631769
None (earliest Version on record)	422	422	1.000000
Eligibility	352	159	2.213837
Outcome Measures	237	150	1.580000
Study Identification	204	143	1.426573
Sponsor/Collaborators	192	136	1.411765
Groups	149	109	1.366972
Interventions	149	109	1.366972
Oversight	130	104	1.250000
References	115	55	2.090909
Conditions	68	56	1.214286
Results	35	35	1.000000
More Information	33	17	1.941177
IPDSharing	30	30	1.000000
Baseline Characteristics	12	11	1.090909
Participant Flow	10	8	1.250000
Reported Adverse Events	10	8	1.250000
Documents	6	5	1.200000
Results Submission Events	6	6	1.000000

Enrollment Metrics

Measure	Observational
Min	1.000
1st Qu	38.000
Median	100.000
Mean	1889.842
3rd Qu	375.500
Max	214962.000

Observation Model

observational_model	Study_Count
Cohort	183
Case-Control	72
NA	53
Case-Only	48
Case Control	31
Other	21
Ecologic or Community	6
Case-Crossover	2
Defined Population	2
Family-Based	2
Defined Population, Natural History	1
Natural History	1

Time Perspective

time_perspective	Study_Count
Prospective	261
Cross-Sectional	89
NA	29
Retrospective	28
Other	11
Longitudinal, Retrospective/Prospective	2
Cross-Sectional, Prospective	1
Cross-Sectional, Retrospective/Prospective	1

Registries

Studies by Country

Country	Study_Count
NA	3
Turkey	3
United States	3
Italy	2
Egypt	1
Israel	1
Korea, Republic of	1
Mexico	1
Netherlands	1
Sweden	1
Taiwan	1
United Kingdom	1
United States\|Canada	1
United States\|Canada\|Israel	1

Sites per Study

Site_count	Study_Count
1	16
2	2
7	2
8	1

Number of Updates

Count of Versions	Count of Studies
1	3
2	6
3	4
4	4
5	2
6	1
12	1

Update History Change Type

Change Type	Count_of_Changes	Count_of_Studies	ratio
Study Status	50	18	2.777778
None (earliest Version on record)	21	21	1.000000
Contacts/Locations	19	13	1.461539
Recruitment Status	12	10	1.200000
Outcome Measures	7	7	1.000000
Study Description	7	7	1.000000
Study Design	6	6	1.000000
Oversight	3	3	1.000000
Eligibility	2	2	1.000000
Groups	2	2	1.000000
Interventions	2	2	1.000000
References	2	2	1.000000
Study Identification	2	2	1.000000
Conditions	1	1	1.000000
IPDSharing	1	1	1.000000

Enrollment Metrics

Measure	Registries
Min	18.0
1st Qu	60.0
Median	300.0
Mean	283249.9
3rd Qu	550.0
Max	5940299.0

Registry Model

observational_model	Study_Count
Cohort	11
Case-Control	4
Case-Only	2
Case Control	1
Ecologic or Community	1
Family-Based	1
Other	1

Time Perspective

time_perspective	Study_Count
Prospective	15
Cross-Sectional	4
Other	1
NA	1

Follow-up

target_duration	Study_Count
1 Day	3
2 Years	3
3 Years	3
5 Years	3
1 Week	2
1 Month	1
13 Weeks	1
15 Years	1
17 Years	1
6 Months	1
7 Days	1
8 Weeks	1

intervention_type	Study_Count
Drug	385
Drug\|placebo	306
Device	200
Other	192
Behavioral	160
Procedure	49
Device\|Other	21
Biological	12
Device\|Drug	12
Dietary Supplement	12
Behavioral\|Other	10
Behavioral\|Device	9
Drug\|Other	9
Device\|placebo	8
Diagnostic Test	8
Dietary Supplement\|placebo	8
Drug\|Procedure	8
Biological\|Other	5
Other\|Procedure	5
Device\|Procedure	4
Genetic	4
Other\|placebo	4
Biological\|placebo	3
Drug\|Other\|placebo	3
Radiation	3
Behavioral\|Drug	2
Behavioral\|Drug\|placebo\|Procedure	2
Behavioral\|Procedure	2
Biological\|Procedure	2
Device\|Diagnostic Test	2
Device\|Drug\|placebo	2
Drug\|Radiation	2
placebo	2
Behavioral\|Biological\|Diagnostic Test\|Other	1
Behavioral\|Device\|Drug	1
Behavioral\|Dietary Supplement\|placebo	1
Behavioral\|Other\|Procedure	1
Behavioral\|Other\|Radiation	1
Behavioral\|placebo	1
Behavioral\|Radiation	1
Biological\|Drug	1
Combination Product	1
Combination Product\|Drug\|placebo	1
Combination Product\|placebo	1
Device\|Diagnostic Test\|Other	1
Device\|Drug\|Other	1
Device\|Drug\|Other\|placebo	1
Device\|Drug\|Other\|Radiation	1
Device\|Genetic	1
Diagnostic Test\|Drug	1
Diagnostic Test\|Other	1
Dietary Supplement\|Drug\|placebo	1
Dietary Supplement\|Other	1
Drug\|Genetic\|Other	1
Drug\|Other\|Radiation	1
Drug\|Procedure\|Radiation	1
Genetic\|Other	1
placebo\|Procedure	1

Country	Study_Count
United States	551
NA	113
France	108
Italy	46
Canada	42
Germany	38
China	36
Brazil	34
United Kingdom	34
Japan	33
Taiwan	26
Spain	25
Korea, Republic of	24
Portugal	18
Sweden	18
Belgium	17
Israel	17
Netherlands	16
Turkey	15
Switzerland	14
United States\|Canada	12
Denmark	10
Austria	8
Australia	5
Finland	5
Norway	5
Finland\|Sweden	4
Austria\|France\|Germany\|Italy\|Spain\|United Kingdom	3
Cuba	3
Egypt	3
France\|United Kingdom	3
Hong Kong	3
Hungary	3
Malaysia	3
Mexico	3
Slovenia	3
Thailand	3
United States\|Puerto Rico	3
Argentina	2
Austria\|Czech Republic\|Hungary\|India\|Italy\|Korea, Republic of\|Philippines\|Poland\|Russian Federation\|Slovakia\|Spain\|Sweden\|Ukraine\|United Kingdom	2
Belgium\|Germany	2
Ireland	2
New Zealand	2
Poland	2
Singapore	2
South Africa	2
United States\|Argentina\|Belgium\|Bulgaria\|Canada\|Chile\|Colombia\|Croatia\|Finland\|India\|Israel\|Mexico\|New Zealand\|Peru\|Romania\|Russian Federation\|Serbia\|Slovakia\|South Africa\|Sweden\|Ukraine	2
United States\|Austria\|France\|Germany\|Spain	2
United States\|Belgium	2
United States\|Canada\|Czechia\|Poland\|Spain	2
United States\|Canada\|Puerto Rico	2
United States\|Germany	2
United States\|Israel	2
United States\|Netherlands	2
Australia\|Austria\|Croatia\|Czech Republic\|Finland\|France\|Germany\|Hungary\|Israel\|Italy\|New Zealand\|Norway\|Poland\|South Africa\|Spain\|Sweden\|United Kingdom	1
Australia\|Canada\|Finland\|France\|Germany\|Italy\|Japan\|Spain	1
Australia\|Germany\|Sweden\|United Kingdom	1
Australia\|Korea, Republic of\|Malaysia\|Singapore\|Taiwan	1
Australia\|New Zealand	1
Australia\|Philippines\|Taiwan\|Thailand	1
Australia\|Spain	1
Austria\|Belgium\|Bulgaria\|Czech Republic\|France\|Germany\|Hungary\|Italy\|Romania\|Slovakia\|Spain\|Switzerland	1
Austria\|Belgium\|Czech Republic\|South Africa\|Estonia\|France\|Germany\|Hungary\|Israel\|Italy\|Lithuania\|Poland\|Portugal\|Serbia\|Spain\|Sweden\|United Kingdom	1
Austria\|Canada\|Denmark\|France\|Germany\|Morocco\|Netherlands\|Portugal\|South Africa\|Spain\|Sweden\|Tunisia\|United Kingdom	1
Austria\|Canada\|France\|Germany\|South Africa	1
Austria\|Czechia\|France\|Germany\|Netherlands\|Portugal\|Spain\|United Kingdom	1
Austria\|Denmark\|France\|Germany\|Netherlands\|Spain\|United Kingdom	1
Austria\|Finland\|France\|Germany\|Italy\|Netherlands\|Norway\|Romania\|Russian Federation\|South Africa\|Spain\|Sweden\|Ukraine	1
Austria\|France\|Germany\|Italy\|Spain	1
Austria\|France\|Germany\|Netherlands\|Spain\|United Kingdom	1
Austria\|Germany\|Italy\|Spain	1
Austria\|Germany\|United Kingdom	1
Belarus	1
Belgium\|Israel	1
Belgium\|Israel\|Italy\|Netherlands\|United Kingdom	1
Belgium\|Netherlands\|United Kingdom	1
Bolivia	1
Brazil\|Canada	1
Bulgaria\|Canada\|Czechia\|France\|Germany\|Hungary\|Italy\|Poland\|Romania\|Russian Federation\|South Africa\|Spain\|Ukraine\|United Kingdom	1
Bulgaria\|Malta\|Serbia	1
Canada\|Finland\|France\|Netherlands\|Spain\|Switzerland\|United Kingdom	1
Canada\|France\|Germany\|United Kingdom	1
Canada\|United States	1
Chile	1
China\|Japan	1
Czech Republic\|France\|Germany\|Italy\|Serbia\|Spain	1
Czech Republic\|Germany\|Hungary\|Poland\|Romania\|Spain\|United Kingdom	1
Czechia	1
Denmark\|Finland\|Germany\|Ireland\|Sweden\|United Kingdom	1
Finland\|Germany\|Hungary\|Latvia	1
France\|Germany	1
France\|Germany\|Netherlands	1
France\|Netherlands	1
France\|Russian Federation	1
France\|United States\|Austria\|Czechia\|Germany\|Israel\|Italy\|Poland\|Spain	1
Germany\|Ireland	1
Germany\|Poland	1
Germany\|South Africa	1
Germany\|Sweden\|United Kingdom	1
Greece	1
Hungary\|United States\|Belgium\|Czech Republic\|France\|Germany\|Italy\|Poland\|Spain	1
Iceland	1
India	1
India\|Israel\|United Kingdom	1
Israel\|Poland\|Serbia	1
Israel\|Serbia\|United Kingdom	1
Italy\|United States\|Canada\|Czechia\|Germany\|Israel\|Poland\|Serbia	1
Japan\|Korea, Republic of\|Taiwan	1
Jordan	1
Norway\|Sweden\|United Kingdom	1
Peru\|United States\|Argentina\|Australia\|Austria\|Belgium\|Colombia\|France\|Germany\|Greece\|Italy\|Mexico\|Puerto Rico\|Spain	1
Poland\|Portugal\|United States\|Australia\|Czech Republic\|Estonia\|France\|Germany\|India\|Italy\|Lithuania\|Malaysia\|Netherlands\|South Africa\|Spain\|Taiwan\|Thailand\|United Kingdom	1
Poland\|Portugal\|United States\|Australia\|Czech Republic\|Estonia\|Germany\|India\|Italy\|Lithuania\|Malaysia\|Netherlands\|South Africa\|Taiwan\|Thailand	1
Portugal\|Romania\|Ukraine	1
Romania\|Ukraine	1
Romania\|United States\|Austria\|Belgium\|Czechia\|France\|Germany\|Hungary\|Israel\|Netherlands\|Poland\|Serbia\|Spain\|United Kingdom	1
Russian Federation	1
Serbia\|United Kingdom	1
Slovakia	1
Slovakia\|Taiwan	1
Spain\|Sweden\|Switzerland\|Australia\|Austria\|Belgium\|Croatia\|Czech Republic\|Finland\|France\|Germany\|Hungary\|Israel\|Italy\|Netherlands\|New Zealand\|Norway\|Poland\|South Africa\|United Kingdom	1
Sweden\|United Kingdom	1
Switzerland\|United States\|Austria\|Canada\|France\|Germany\|Hungary\|Italy\|Slovakia\|Spain	1
United States\|Albania\|Argentina\|Brazil\|Bulgaria\|Canada\|Chile\|Colombia\|Latvia\|Lithuania\|Peru\|Russian Federation\|Ukraine	1
United States\|Argentina\|Australia\|Austria\|Belgium\|Canada\|France\|Germany\|Italy\|Netherlands\|Spain\|Turkey\|United Kingdom	1
United States\|Argentina\|Austria\|Czech Republic\|Finland\|Germany\|Hungary\|India\|Japan\|Malaysia\|Russian Federation\|Slovakia\|Taiwan\|Ukraine	1
United States\|Argentina\|Brazil\|Bulgaria\|Canada\|Chile\|Colombia\|Croatia\|Czech Republic\|Finland\|Germany\|India\|Italy\|Mexico\|Peru\|Poland\|Portugal\|Slovakia\|South Africa\|Spain	1
United States\|Argentina\|Brazil\|Bulgaria\|Canada\|Chile\|Colombia\|Latvia\|Lithuania\|Peru\|Russian Federation\|Ukraine	1
United States\|Argentina\|Canada\|Chile\|Romania\|Ukraine	1
United States\|Argentina\|Chile\|Estonia\|Korea, Republic of\|Russian Federation\|Slovakia	1
United States\|Argentina\|Mexico\|Puerto Rico	1
United States\|Australia	1
United States\|Australia\|Austria\|Belgium\|Canada\|Estonia\|France\|Germany\|Hungary\|India\|Israel\|Korea, Republic of\|Malaysia\|Netherlands\|New Zealand\|Slovakia\|Spain\|Switzerland\|Taiwan\|Thailand\|United Kingdom	1
United States\|Australia\|Austria\|Finland\|Germany\|Hungary\|Italy\|New Zealand\|Poland\|South Africa\|Spain\|United Kingdom	1
United States\|Australia\|Austria\|France\|Germany\|Greece\|Israel\|Italy\|Norway\|Spain\|United Kingdom	1
United States\|Australia\|Belgium\|Canada\|Denmark\|Germany\|Italy\|Japan\|Netherlands\|Russian Federation\|Spain\|Sweden\|United Kingdom	1
United States\|Australia\|Belgium\|Canada\|Denmark\|Italy\|Japan\|Netherlands\|Spain\|United Kingdom	1
United States\|Australia\|Canada\|Czech Republic\|Finland\|Germany\|Israel\|Italy\|Netherlands\|New Zealand\|Poland\|Portugal\|Russian Federation\|Spain\|Thailand\|United Kingdom	1
United States\|Australia\|Canada\|Czechia\|Israel\|New Zealand\|Poland\|Portugal\|Russian Federation\|Thailand\|United Kingdom	1
United States\|Australia\|Canada\|France\|Germany\|Italy	1
United States\|Australia\|Canada\|Germany\|Greece\|Italy\|Korea, Republic of\|Spain\|Sweden	1
United States\|Australia\|France	1
United States\|Austria\|Belgium\|Canada\|Finland\|France\|Germany\|Greece\|Italy\|Spain\|Sweden\|Switzerland\|Turkey\|United Kingdom	1
United States\|Austria\|Belgium\|Canada\|France\|India\|Italy\|Poland\|Portugal\|Russian Federation\|Serbia\|Sweden\|Ukraine\|United Kingdom	1
United States\|Austria\|Belgium\|Italy\|Poland\|Portugal\|Serbia\|Spain\|Sweden	1
United States\|Austria\|Canada\|Czechia\|France\|Germany\|Italy	1
United States\|Austria\|Canada\|France	1
United States\|Austria\|Canada\|France\|Germany\|Greece\|Israel\|Italy\|Japan\|Norway\|Portugal\|Singapore\|Spain\|Sweden\|Taiwan\|United Kingdom	1
United States\|Austria\|Canada\|France\|Germany\|Hungary\|Italy\|Slovakia\|Spain\|Switzerland	1
United States\|Austria\|Canada\|France\|Germany\|Israel\|Italy\|Spain\|United Kingdom	1
United States\|Austria\|Canada\|France\|Germany\|Italy\|Spain\|United Kingdom	1
United States\|Austria\|Czech Republic\|Finland\|France\|Germany\|Hungary\|India\|Japan\|Malaysia\|Netherlands\|Russian Federation\|Slovakia\|Taiwan\|Ukraine	1
United States\|Austria\|Czechia\|Hungary\|Israel\|Poland\|Spain	1
United States\|Austria\|Finland\|France\|Germany\|Italy\|Japan\|Spain\|Sweden\|United Kingdom	1
United States\|Austria\|France\|Germany	1
United States\|Austria\|France\|Germany\|Spain\|United Kingdom	1
United States\|Austria\|Germany\|Israel\|Italy\|South Africa\|Spain\|United Kingdom	1
United States\|Austria\|Hungary\|Poland\|Slovakia\|Slovenia\|Spain	1
United States\|Austria\|Israel\|Italy	1
United States\|Belgium\|Bulgaria\|Canada\|France\|Germany\|Hungary\|Portugal\|Romania\|South Africa\|United Kingdom	1
United States\|Belgium\|Czech Republic\|France\|Hungary\|Italy\|Poland\|Spain\|United Kingdom	1
United States\|Belgium\|France	1
United States\|Belgium\|Germany\|Italy\|Poland\|Spain	1
United States\|Brazil\|Canada\|France\|Germany\|Italy\|Netherlands\|Portugal\|United Kingdom	1
United States\|Bulgaria\|France\|India\|Russian Federation\|Ukraine\|United Kingdom	1
United States\|Canada\|Czech Republic\|France\|Germany\|Hungary\|Poland\|Romania\|Serbia\|United Kingdom	1
United States\|Canada\|Czech Republic\|Germany\|Israel\|Italy\|Poland\|Serbia	1
United States\|Canada\|Czechia\|Israel\|Italy\|Poland\|Portugal\|Turkey	1
United States\|Canada\|Estonia\|Germany\|Latvia\|Lithuania\|Poland\|Romania\|Spain\|Ukraine	1
United States\|Canada\|Estonia\|Latvia\|Lithuania\|Romania\|Ukraine	1
United States\|Canada\|France\|Germany\|Hungary\|Italy\|Spain	1
United States\|Canada\|France\|Germany\|Poland\|Romania\|Spain\|Ukraine	1
United States\|Canada\|Germany\|Spain	1
United States\|Canada\|Israel\|Italy\|Korea, Republic of\|Spain\|Taiwan\|United Kingdom	1
United States\|Canada\|Israel\|Norway\|Spain\|United Kingdom	1
United States\|Chile\|India\|Mexico\|Peru	1
United States\|Czechia\|France\|Germany\|Hungary	1
United States\|Czechia\|France\|Germany\|Italy\|Spain	1
United States\|Czechia\|France\|Germany\|Italy\|Spain\|United Kingdom	1
United States\|Estonia\|Germany\|Hungary\|Poland\|Slovakia	1
United States\|Estonia\|Korea, Republic of\|Russian Federation\|Slovakia	1
United States\|Finland\|Greece\|Hungary\|Italy\|Slovakia\|Spain	1
United States\|France\|Germany\|Italy	1
United States\|Germany\|New Zealand	1
United States\|Germany\|Poland\|Slovakia	1
United States\|Germany\|United Kingdom	1
United States\|Guatemala\|Romania	1
United States\|Hungary\|Poland\|Slovakia\|Spain	1
United States\|India	1
United States\|India\|Italy	1
United States\|Italy	1
United States\|Italy\|Serbia\|United Kingdom	1
United States\|Korea, Republic of\|Malaysia\|Singapore\|Taiwan	1
United States\|New Zealand	1
United States\|Spain	1
United States\|United Kingdom	1

Count of Versions	Count of Studies
1	179
2	249
3	200
4	173
5	138
6	88
7	73
8	59
9	41
10	34
11	28
12	27
13	20
14	18
15	13
16	13
17	7
18	12
19	11
20	14
21	9
22	8
23	6
24	10
25	3
26	4
27	2
28	3
29	2
30	3
31	2
32	4
33	7
34	2
36	3
37	1
38	1
39	2
50	2
51	2
52	2
60	2
64	1
73	1
86	1
110	1

Site_count	Study_Count
1	329
2	19
3	11
4	5
5	6
6	4
7	3
8	1
9	1
10	1
12	3
13	2
14	1
15	3
20	1
21	1
24	2
27	2
30	2
32	1
42	1
49	1
52	1
54	2
57	2
58	1
59	1
76	1
98	1
102	1
103	1
118	1
119	1
140	1
211	1
215	1
238	1
273	1
278	1
284	1
311	1
317	1

Count of Versions	Count of Studies
1	58
2	69
3	59
4	51
5	33
6	30
7	18
8	14
9	15
10	3
11	2
12	5
13	5
14	4
15	4
16	7
17	5
18	4
19	3
20	2
21	1
22	1
23	1
24	2
25	1
26	3
27	2
28	2
32	1
35	1
37	1
38	1
46	1
50	1
64	1
66	1
78	2
93	1
97	1
103	1
110	1
115	1
120	1
123	1
172	1

Count of Versions	Count of Studies
1	179
2	249
3	200
4	173
5	138
6	88
7	73
8	59
9	41
10	34
11	28
12	27
13	20
14	18
15	13
16	13
17	7
18	12
19	11
20	14
21	9
22	8
23	6
24	10
25	3
26	4
27	2
28	3
29	2
30	3
31	2
32	4
33	7
34	2
36	3
37	1
38	1
39	2
50	2
51	2
52	2
60	2
64	1
73	1
86	1
110	1

Site_count	Study_Count
1	329
2	19
3	11
4	5
5	6
6	4
7	3
8	1
9	1
10	1
12	3
13	2
14	1
15	3
20	1
21	1
24	2
27	2
30	2
32	1
42	1
49	1
52	1
54	2
57	2
58	1
59	1
76	1
98	1
102	1
103	1
118	1
119	1
140	1
211	1
215	1
238	1
273	1
278	1
284	1
311	1
317	1

Count of Versions	Count of Studies
1	58
2	69
3	59
4	51
5	33
6	30
7	18
8	14
9	15
10	3
11	2
12	5
13	5
14	4
15	4
16	7
17	5
18	4
19	3
20	2
21	1
22	1
23	1
24	2
25	1
26	3
27	2
28	2
32	1
35	1
37	1
38	1
46	1
50	1
64	1
66	1
78	2
93	1
97	1
103	1
110	1
115	1
120	1
123	1
172	1

parkinson disease

Study Counts

Studies over Time

Interventional Trials

Intervention Type

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Studies by Country

Sites per Study

Phase

Number of Arms

Number of Updates

Update History Change Type

Enrollment Metrics by Phase

Trial Group Type

Intervention Model

Primary Purpose

Observational Studies

Studies by Country

Sites per Study

Number of Updates

Update History Change Type

Enrollment Metrics

Observation Model

Time Perspective

Registries

Studies by Country

Sites per Study

Number of Updates

Update History Change Type

Enrollment Metrics

Registry Model

Time Perspective

Follow-up

Count of Versions	Count of Studies
1	179
2	249
3	200
4	173
5	138
6	88
7	73
8	59
9	41
10	34
11	28
12	27
13	20
14	18
15	13
16	13
17	7
18	12
19	11
20	14
21	9
22	8
23	6
24	10
25	3
26	4
27	2
28	3
29	2
30	3
31	2
32	4
33	7
34	2
36	3
37	1
38	1
39	2
50	2
51	2
52	2
60	2
64	1
73	1
86	1
110	1

Site_count	Study_Count
1	329
2	19
3	11
4	5
5	6
6	4
7	3
8	1
9	1
10	1
12	3
13	2
14	1
15	3
20	1
21	1
24	2
27	2
30	2
32	1
42	1
49	1
52	1
54	2
57	2
58	1
59	1
76	1
98	1
102	1
103	1
118	1
119	1
140	1
211	1
215	1
238	1
273	1
278	1
284	1
311	1
317	1

Count of Versions	Count of Studies
1	58
2	69
3	59
4	51
5	33
6	30
7	18
8	14
9	15
10	3
11	2
12	5
13	5
14	4
15	4
16	7
17	5
18	4
19	3
20	2
21	1
22	1
23	1
24	2
25	1
26	3
27	2
28	2
32	1
35	1
37	1
38	1
46	1
50	1
64	1
66	1
78	2
93	1
97	1
103	1
110	1
115	1
120	1
123	1
172	1